Tommy Andersson

Professor

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • WNT5A, Melanoma, Breast Cancer

Research

Our studies are focused on the revelation of WNT5A, a secreted glycoprotein. WNT5A belongs to the non-transforming class of WNTs, and upon binding to different receptors or co-receptor complexes (Frizzled, RYK, ROR1/2, LRP5/6 and CD146), it elicits non-canonical (β-catenin-independent) signaling. WNT5A act as both tumor promoter as well as tumor suppressor, depending on cell type. For example, in breast cancer loss of WNT5A protein is associated with poor survival. In contrast, WNT5A expression is associated with increased metastasis and reduced survival in melanoma patients.  Our laboratory focusses on how WNT5A expression is regulated in these cancers and deciphering the WNT5A signaling pathways governing cancer cell migration and invasion.
On therapeutic front, we have developed a hexapeptide, Foxy5 (an agonist of WNT5A) which is currently in Phase1 clinical trial for breast cancer, prostate cancer and colon carcinoma (NCT02020291). Another peptide, Box5 (a WNT5A derived antagonist) is currently in pre-clinical trials for malignant melanoma.

Highlighted research outputs

Prasad, C., Purusottam Mohapatra & Tommy Andersson, 2015, In : Cancers. 7, 3, p. 1900-1924

Research output: Contribution to journalReview article

Linnskog, R., Gunilla Jönsson, Lena Axelsson, Prasad, C. & Tommy Andersson, 2014, In : Molecular Oncology. 8, 8, p. 1365-1378

Research output: Contribution to journalArticle

Sherwood, V., Chaurasiya, S., Ekström, E., Guilmain, W., Liu, Q., Koeck, T., Brown, K., Hansson, K. M., Agnarsdóttir, M., Bergqvist, M., Karin Jirström, Ponten, F., Peter James & Tommy Andersson, 2014, In : Carcinogenesis. 35, 4, p. 784-794

Research output: Contribution to journalArticle

Prasad, C. P., Chaurasiya, S. K., Lena Axelsson & Tommy Andersson, 2013 Oct, In : Molecular Oncology. 7, 5, p. 870-83 14 p.

Research output: Contribution to journalArticle

Sand-Dejmek, J., Ehrnström, R., Berglund, P., Tommy Andersson & Lisa Rydén, 2013, In : PLoS ONE. 8, 8, e70890.

Research output: Contribution to journalArticle

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