Yvonne Ceder

ResearcherFormer name: Yvonne Olsson

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • microRNA, Prostate cancer, Exosomes

Research

Prostate cancer is the most common form of cancer in men. The manifestation of distant metastasis is the major cause of cancer-related deaths. The metastatic dissemination is an inefficient, complex and dynamic process, involving tumour cells detaching from the primary tumour site, entering the bloodstream, extravasation at distant locations and establishing secondary tumours. The reciprocal regulation of miRNA and their targets has been established as crucial regulators of the balance between epithelial and mesenchymal differentiation states, as well as cancer stem cell regulation.

We focus on the miRNA regulation of the transient processes leading to metastases as the reversibility of this type of regulation present a possible interference option. Different miRNAs have evolved to coordinate the regulation of hundreds of genes involved in coordinated cellular functions. When these functions are disrupted in e.g. cancer progression, they provide a strategy to target systems rather than one-gene-at-a-time in a fine-tuned manner. We perform molecular and functional characterisation of primary tumour cells, the heterogeneous population of circulating tumour cells and exosomes, and confirm our findings in clinical cohorts. To identify the molecular characteristics defining the different steps of tumour progression and metastatic spread, will increase the understanding of cancer metastasis and can also lead to the development of improved patient-oriented strategies for combating cancer, and provide novel means to monitor the disease progression and treatment response.

Highlighted research outputs

Olivia Larne, Zandra Hagman, Hans Lilja, Anders Bjartell, Anders Edsjö & Yvonne Ceder, 2015, In : Carcinogenesis. 36, 8, p. 858-866

Research output: Contribution to journalArticle

Olivia Larne, Päivi Östling, Benedikta Haflidadottir, Zandra Hagman, Anna Aakula, Pekka Kohonen, Olli Kallioniemi, Anders Edsjö, Anders Bjartell, Hans Lilja, Åke Lundwall & Yvonne Ceder, 2015, In : European Urology. 68, 4, p. 581-588

Research output: Contribution to journalArticle

Olivia Larne, Elena Martens-Uzunova, Zandra Hagman, Anders Edsjö, Giuseppe Lippolis, Mirella S Vredenbregt-van den Berg, Anders Bjartell, Guido Jenster & Yvonne Ceder, 2013, In : International Journal of Cancer. 132, 12, p. 2867-2875

Research output: Contribution to journalArticle

Päivi Ostling, Suvi-Katri Leivonen, Anna Aakula, Pekka Kohonen, Rami Mäkelä, Zandra Hagman, Anders Edsjö, Sara Kangaspeska, Henrik Edgren, Daniel Nicorici, Anders Bjartell, Yvonne Ceder, Merja Perälä & Olli Kallioniemi, 2011, In : Cancer Research. 71, p. 1956-1967

Research output: Contribution to journalArticle

Zandra Hagman, Olivia Larne, Anders Edsjö, Anders Bjartell, Roy Ehrnström, David Ulmert, Hans Lilja & Yvonne Ceder, 2010, In : International Journal of Cancer. 127, 12, p. 2768-2776

Research output: Contribution to journalArticle

View all (40)