Yvonne Ceder

ResearcherFormer name: Yvonne Olsson

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • microRNA, Prostate cancer, Exosomes

Research

Prostate cancer is the most common form of cancer in men. The manifestation of distant metastasis is the major cause of cancer-related deaths. The metastatic dissemination is an inefficient, complex and dynamic process, involving tumour cells detaching from the primary tumour site, entering the bloodstream, extravasation at distant locations and establishing secondary tumours. The reciprocal regulation of miRNA and their targets has been established as crucial regulators of the balance between epithelial and mesenchymal differentiation states, as well as cancer stem cell regulation.

We focus on the miRNA regulation of the transient processes leading to metastases as the reversibility of this type of regulation present a possible interference option. Different miRNAs have evolved to coordinate the regulation of hundreds of genes involved in coordinated cellular functions. When these functions are disrupted in e.g. cancer progression, they provide a strategy to target systems rather than one-gene-at-a-time in a fine-tuned manner. We perform molecular and functional characterisation of primary tumour cells, the heterogeneous population of circulating tumour cells and exosomes, and confirm our findings in clinical cohorts. To identify the molecular characteristics defining the different steps of tumour progression and metastatic spread, will increase the understanding of cancer metastasis and can also lead to the development of improved patient-oriented strategies for combating cancer, and provide novel means to monitor the disease progression and treatment response.

Highlighted research outputs

Larne, O., Hagman, Z., Hans Lilja, Anders Bjartell, Edsjö, A. & Yvonne Ceder, 2015, In : Carcinogenesis. 36, 8, p. 858-866

Research output: Contribution to journalArticle

Larne, O., Östling, P., Haflidadottir, B., Hagman, Z., Aakula, A., Kohonen, P., Kallioniemi, O., Edsjö, A., Anders Bjartell, Hans Lilja, Åke Lundwall & Yvonne Ceder, 2015, In : European Urology. 68, 4, p. 581-588

Research output: Contribution to journalArticle

Larne, O., Martens-Uzunova, E., Hagman, Z., Edsjö, A., Lippolis, G., Vredenbregt-van den Berg, M. S., Anders Bjartell, Jenster, G. & Yvonne Ceder, 2013, In : International Journal of Cancer. 132, 12, p. 2867-2875

Research output: Contribution to journalArticle

Ostling, P., Leivonen, S-K., Aakula, A., Kohonen, P., Mäkelä, R., Hagman, Z., Edsjö, A., Kangaspeska, S., Edgren, H., Nicorici, D., Anders Bjartell, Yvonne Ceder, Perälä, M. & Kallioniemi, O., 2011, In : Cancer Research. 71, p. 1956-1967

Research output: Contribution to journalArticle

Hagman, Z., Larne, O., Edsjö, A., Anders Bjartell, Ehrnström, R., David Ulmert, Hans Lilja & Yvonne Ceder, 2010, In : International Journal of Cancer. 127, 12, p. 2768-2776

Research output: Contribution to journalArticle

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