Contact system project

Project: Research

Research areas and keywords

UKÄ subject classification

  • Infectious Medicine

Description

Hemostasis is a sensitive and tightly regulated process, involving vascular endothelium and blood cells as well as factors of the coagulation and fibrinolytic cascades. During infection, inflammatory mediators of the microbe and/or host may induce life-threatening complications by modulating the equilibrium between the procoagulant and anticoagulant status of the host. Over the last few years, evidence has been accumulating that activation of the intrinsic pathway of coagulation (also termed the contact system or kallikrein/kinin system) contributes to the severity of the disease. As described for other factors participating in blood coagulation, the contact system belongs to the typical serine proteinase-triggered cascades, which are initiated by limited proteolysis. Upon activation, the contact system is involved in the regulation of different pro-inflammatory and defense machineries, which can induce symptoms that are also seen in patients with severe infections.We recently found that inhibition of the contact system down-regulates inflammatory reactions in a mouse model of sepsis (1). This project is undertaken to gain more insight into the mechanisms that lead to a bacteria-induced induction of this part of the coagulation cascade and a subsequent activation of clotting factors up-stream of the contact system.
StatusActive
Effective start/end date2010/01/01 → …

Participants

Related research output

Vieira, M., Naudin, C., Mörgelin, M., Romero, E. C., Nascimento, A. L. T. O. & Heiko Herwald, 2016 May 11, In : PLoS Neglected Tropical Diseases. 10, 5, e0004713.

Research output: Contribution to journalArticle

Naudin, C., Hurley, S., Erik Malmström, Plug, T., Oonagh Shannon, Meijers, J. C. M., Mörgelin, M., Lars Björck & Heiko Herwald, 2015, In : Thrombosis and Haemostasis. 114, 4, p. 717-726

Research output: Contribution to journalArticle

van der Poll, T. & Heiko Herwald, 2014, In : Thrombosis and Haemostasis. 112, 4, p. 640-648

Research output: Contribution to journalArticle

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