Effects of the antimicrobial peptide LL-37 on host cell viability

Project: Research

Research areas and keywords

UKÄ subject classification

  • Medical and Health Sciences

Description

The human host defense peptide LL-37 combats microrganisms through different mechanisms, e.g. via permeabilization of the bacterial cell-wall. Our data suggest that LL-37 also reduces host cell viability and that the organism is equiped with protective mechanisms to inhibit the deleterious effects of LL-37. We are interested in the balance between beneficial effects of LL-37 and its cytotoxic effects that may influence host cells especially locally at the site of the inflammation.
StatusActive
Effective start/end date2013/11/01 → …

Participants

Related research output

Johanna Säll, Carlsson, M., Olof Gidlöf, Holm, A., Humlén, J., Öhman, J., Daniel Svensson, Bengt-Olof Nilsson & Daniel Jönsson, 2013, In : Journal of Innate Immunity. 5, 3, p. 290-300

Research output: Contribution to journalArticle

View all (3)