Hemodynamic Stabilization

Project: Research

Research areas and keywords

UKÄ subject classification

  • Control Engineering
  • Anesthesiology and Intensive Care


Intensive care patients often rely on a combination of drug, fluid, and other therapies to achieve and maintain stable hemodynamics. This projects investigates how pharmacology, mathematical modeling, signal processing and closed-loop control can be combined to control hemodynamic entities such as blood pressure, heart rate, and vascular resistance, as well as related entities such as diuresis. The research relies on close inter-disciplinary collaboration between medical and control systems researchers. It is conducted in a systems engineering framework and comprises the development of both methods and dedicated equipment for clinical verification.

The aim of the project is to develop methods for hemodynamic stabilization of intensive care patients. It comprises closed-loop control of readily measurable signals, including heart rate, arterial and venous blood pressure. Furthermore, the project aims at optimizing hemodynamic parameters, which are not directly measurable, such as cardiac output and responsiveness to volume expansion.

The aim of the project is to develop a generic platform for closed-loop intravenous drug delivery. Apart from being used in research, such a platform can be adapted to a multitude och medical treatment scenaraios, foremost in intensive care, where it has the potential to increase the availability of specialized physicians.

The aim of the project is to provide physicians with an 'auto pilot' for hemodynamic stabilizatioin and optimization. The initially considered patient group are heart-beating braindead patients under intensive care (potential organ donors). Due to the complete loss of vasomotor center function, hormonal and fluid therapy is required to establish hemodynamic stability within this group.

We combine automatic control methods with medical insight, to develop closed-loop controlled therapies. Developed methods are implemented on our in-house developed control system comprising sensors for invasive blood pressure measurement, and urination rate, as well as syringe and volumetric infusion, pumps for closed-loop controlled intravenous drug and fluid administration.

The methods are pre-clinically evaluated in collaboration with the project partner Igelösa Life Science AB.

In 2018, Henry Pigot joined the team as PhD student. His project is strongly related to the above project, but with ex vivo heart evaluation as application scenario. Henry and other collaborators are currently developing a research setup enabling the evaluation of hearts ex vivo, with the purpose of classifying whether they are suitable for transplantation. The same setup will also be a valuable tool in basic physiology and pharmacology research, in conjecture with the aforementioned closed-loop drug delivery system.

Another project activity during 2018 was an extended research visit by PhD student José Cava Gonzales from Spain. José has made theoretical contributions to individualization of closed-loop intravenous therapies. A journal manuscript intended for IEEE Transactions on control systems technology is in preparation.
Effective start/end date2016/09/012022/12/31

Collaborative partners


Related research output

Kristian Soltesz, van Heusden, K. & Dumont, G. A., 2019, (Submitted) Automated drug delivery in anesthesia. Elsevier

Research output: Chapter in Book/Report/Conference proceedingBook chapter

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Related activities

Soltesz, K. (Second supervisor)
2018 Sep 32018 Dec 21

Activity: Examination and supervisionSupervision of PhD students

Soltesz, K. (Host)
2018 Sep 32018 Dec 21

Activity: Hosting a visitor

Soltesz, K. (Host)
2018 Aug 32019 Jul 31

Activity: Hosting a visitor

View all (16)