Identifying periorbital tumor margins using new non-invasive imaging techniques

Project: Research

Research areas and keywords

UKÄ subject classification

  • Ophthalmology
  • Medical and Health Sciences
  • Medical Image Processing



The only way to measure tumor infiltration in periorbital tissue is by excising it surgically and then analyzing it histologically after surgery. The aim of the present project is to develop and test two new non-invasive imaging techniques to determine the tumor margin before surgery. This would enable more reliable tumor resection, as there would be less risk of leaving malignant cells. This would greatly benefit the patient and reduce health care costs as fewer surgical procedures would be necessary.

The project is both experimental and clinical, and is being performed in collaboration with researchers at the Faculty of Engineering, Lund University.

1. Diffuse reflectance spectroscopy (DRS) examines the molecular composition of tissue spectroscopically using broad-spectrum light. In a previous study, we demonstrated clear differences between the optical signatures from tumor and non-tumor tissue in the liver. We now intend to adapt the technique so that we can identify periorbital tumor edges before surgery.

2. Photoacoustic imaging (PAI) provides high-resolution 3D images of the structure and function of tissue by irradiating it with laser light and radiofrequency pulses, which generate ultrasound. Animal studies show excellent high-resolution images of tumors. No studies have yet been performed to image periorbital tumors in patients.

If DRS and/or PAI are found to be useful clinical tools for tumor delineation in periorbital tumor surgery, they may also be applicable in other specialties.
Effective start/end date2016/01/01 → …

Collaborative partners