inflammatory events leading to autoimmune Diabetes

Project: ResearchIndividual research project, International collaboration

Description

Here we investigate inflammatory events initiating the development of type-1 diabetes and cellular events promoting disease progression. Therefore we have recently established that transplantation of pancreatic islets to the ACE and longitudinally imaging by 2-Photon microscopy can be used to follow the migration of single cells in islet grafts (Schmidt-Christensen et al., Diabetologia 2013). Together with Theo Lasser ´s group at EPFL in Lausanne we describe a further developed labelfree technique (Berclaz et. al, Diabetologia 2016). By introducing a novel label-free approach, it is now possible to visualize and follow the same mouse and human islets of Langerhans, their structure and early indicators of disease progression like inflammation and changing vasculature repeatedly and over a long period of time.
StatusActive
Effective start/end date2009/10/01 → …

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Participants

Related research output

Corinne Berclaz, Daniel Szlag, David Nguyen, Jérôme Extermann, Arno Bouwens, Paul J. Marchand, Julia Nilsson, Anja Schmidt-Christensen, Dan Holmberg, Anne Grapin-Botton & Theo Lasser, 2016 Nov 1, In: Biomedical Optics Express. 7, 11, p. 4569-4580 12 p., #273588.

Research output: Contribution to journalArticle

Lisbeth Hansen, Anja Schmidt-Christensen, Shashank Gupta, Nina Fransén Pettersson, Tine Hannibal, Boris Reizis, Pere Santamaria & Dan Holmberg, 2015 Dec 1, In: PLoS ONE. 10, 12, e0144090.

Research output: Contribution to journalArticle

Corinne Berclaz, Anja Schmidt-Christensen, Daniel Szlag, Jerome Extermann, Lisbeth Hansen, Arno Bouwens, Martin Villiger, Joan Goulley, Frans Schuit, Anne Grapin-Botton, Theo Lasser & Dan Holmberg, 2015, In: Diabetologia.

Research output: Contribution to journalArticle

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Related activities

Schmidt-Christensen, A. (Invited speaker)
2019 Nov 14

Activity: Talk or presentationPresentation

Schmidt-Christensen, A. (Presenter)
2019 Sep 11

Activity: Talk or presentationPresentation

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