Joint disease collagen biomarkers – discovery and application

Project: Dissertation

Research areas and keywords

Keywords

  • Biomarkers, Collagen, Osteoarthritis, Cartilage, Arthritis, Proteomics

Description

Osteoarthritis (OA) is a severe chronic disabling disease characterized by an abnormal destruction of articular cartilage, which eventually results in joint pain and a loss of peripheral joint function. However, the exact mechanisms that mediate the catabolic events leading to the destruction of the cartilage are yet poorly understood. Diagnosis is late since technology to detect the early cases is lacking. Current project will add to our understanding of the target tissue biology and identify molecular alterations and their mechanisms in pathology that are central to development of joint failure. New findings will be coupled to new therapeutic candidates, as well as development of novel biomarkers of joint tissue turnover allowing early detection and disease monitoring. Thus there will be fine balance between basic research and development towards a commercial target.
StatusActive
Effective start/end date2016/05/012020/03/31

Collaborative partners

Participants

Related research output

Luo, Y., Dovile Sinkeviciute, He, Y., Karsdal, M. A., Henrotin, Y., Mobasheri, A., Patrik Önnerfjord & Bay-Jensen, A., 2017, In : Protein and Cell. 8, 8, p. 560-572

Research output: Contribution to journalArticle

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