Membrane damage and tumor targeted siRNA delivery

Project: DissertationIndividual research project

Research areas and keywords

UKÄ subject classification

  • Cell Biology
  • Biochemistry and Molecular Biology


The aim of this thesis is to identify new strategies to improve the delivery of small. interfering RNAs (siRNAs) to tumor cells, with special focus on enhancing the release of siRNAs from endosomes and lysosomes. The project includes implementation and development of new methods to investigate and characterize aspects of intracellular siRNA delivery, the basal rate of siRNA endosomal escape and how this can be modulated by cellular and pharmacological substances.
Effective start/end date2016/09/01 → …