Numerical investigations of tendon mechanobiology in intact and healing tendon
Project: Dissertation › Interdisciplinary research, National collaboration, Individual research project
Research areas and keywords
- tendon, mechanobiology, biomechanics, computational biology, finite element analysis, healing
In the first project we studied the effect of a reduction in loading on the mechanical properties in intact rat Achilles tendon. We used an established Fibre-reinforced poro-visco-hyper-elastic material model to identify the change in mechanical properties characterized by a period of reduced loading. We developed a novel parameter identification method by incorporating mechanical data from different mechanical tests to identify a general set of parameters to characterize tendon behaviour. This project was finalized by a publication in the Journal of Mechanical Behaviour of Biomedical Materials.
In the following projects, we focus on mechanobiology in tendon healing rather than intact tendon. An adaptive healing framework was created using the previously used material model to describe the evolution of tendon properties throughout early healing. Our main interest is to predict the spatio-temporal evolution of collagen producion and reorientation as well as the temporal evolution of overal mechanical properties such as tendon stiffness. In addition, the effect of reduced loading on tendon healing is investigated.
|Short title||Numerical investigations of tendon mechanobiology in intact and healing tendon|
|Effective start/end date||2017/03/01 → 2021/02/28|
Related research output
Research output: Contribution to journal › Article