Precision Medicine in Hereditary Cancer and Sarcoma; targeted surveillance, immunotherapy and individualized follow-up

Project: Research

Research areas and keywords

UKÄ subject classification

  • Medical and Health Sciences

Keywords

  • cancer, Hereditary cancer, Sarcoma, Colorecal cancer

Description

This proposal describes epidemiologic approaches, genomic profiling and immunogenic expression analyses aimed to refine diagnostics, individualize surveillance and develop precision medicine for hereditary colorectal cancer and soft tissue sarcoma. These rare tumor types are interconnected through hypermutability/genetic complexity and immunotherapy-based treatment possibilities.
The aims of the three substudies relate to:

1. Risk modelling for individualized surveillance and follow-up in
- the hereditary colorectal cancer subsets Lynch syndrome, familial colorectal cancer type X and late onset colorectal cancer through analyses of the risk of extracolonic cancers, interval cancers and metachronous cancers and determination of causes of death
- radiation-induced sarcoma

2. Molecular taxonomy studies of
- extracolonic cancers in Lynch syndrome
- radiation-induced angiosarcoma

3. Prediction of benefit from immunotherapy through
- delineation of an immune-response signature in mismatch-repair deficient colorectal cancers linked to Lynch syndrome
- evaluation of PD-L1 expression in sarcoma for prediction of response and resistance to PD-1 inhibitory treatment of advanced disease

Layman's description

This proposal describes epidemiologic approaches, genomic profiling and immunogenic expression analyses aimed to refine diagnostics, individualize surveillance and develop precision medicine for hereditary colorectal cancer and soft tissue sarcoma. These rare tumor types are interconnected through hypermutability/genetic complexity and immunotherapy-based treatment possibilities.

Short titlePrecision Medicine in Hereditary Cancer and Sarcoma
StatusFinished
Effective start/end date2017/01/012018/12/31

Participants

Related research output

Anna Rohlin, Rambech, E., Anders Kvist, Therese Törngren, Eiengård, F., Lundstam, U., Zagoras, T., Samuel Gebre-Medhin, Åke Borg, Björk, J., Mef Nilbert & Nordling, M., 2017 Apr, In : Familial Cancer. 16, 2, p. 195-203

Research output: Contribution to journalArticle

Lagerstedt-Robinson, K., Rohlin, A., Aravidis, C., Melin, B., Nordling, M., Stenmark-Askmalm, M., Lindblom, A. & Mef Nilbert, 2016 Nov 1, In : Oncology Reports. 36, 5, p. 2823-2835 13 p.

Research output: Contribution to journalArticle

Fredrik Liedberg, Ulf Gerdtham, Gralén, K., Gudjonsson, S., Jahnson, S., Johansson, I., Oskar Hagberg, Larsson, S., Lind, A. K., Anneli Löfgren, Wanegård, J., Åberg, H. & Mef Nilbert, 2016, In : British Journal of Cancer. 115, p. 770-775

Research output: Contribution to journalArticle

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