Precision Medicine in Hereditary Cancer and Sarcoma; targeted surveillance, immunotherapy and individualized follow-up

Project: Research

Description

This project is based on epidemiologic approaches, genomic profiling and immunogenic expression analyses aimed to refine diagnostics, individualize surveillance and develop precision medicine for hereditary colorectal cancer and soft tissue sarcoma. These rare tumor types are interconnected through hypermutability/genetic complexity and immunotherapy-based treatment possibilities. The projects are coordinated by the main applicant (Mef Nilbert) and are built on collaborative efforts within a multiprofessional environment hosting epidemiologists, basic scientists, bioinformaticians, biostatisticians, pathologists, surgeons, oncologists and researchers in training.

SPECIFIC AIMS

The aims of the three substudies relate to:

1. Risk modelling for individualized surveillance and follow-up in
- the hereditary colorectal cancer subsets Lynch syndrome, familial colorectal cancer type X and late onset colorectal cancer through analyses of the risk of extracolonic cancers, interval cancers and metachronous cancers and determination of causes of death
- radiation-induced sarcoma

2. Molecular taxonomy studies of
- extracolonic cancers in Lynch syndrome
- radiation-induced angiosarcoma

3. Prediction of benefit from immunotherapy through
- delineation of an immune-response signature in mismatch-repair deficient colorectal cancers linked to Lynch syndrome
- evaluation of PD-L1 expression in sarcoma for prediction of response and resistance to PD-1 inhibitory treatment of advanced disease


Layman's description

This project is based on epidemiologic approaches, genomic profiling and immunogenic expression analyses aimed to refine diagnostics, individualize surveillance and develop precision medicine for hereditary colorectal cancer and soft tissue sarcoma. These rare tumor types are interconnected through hypermutability/genetic complexity and immunotherapy-based treatment possibilities. The projects are coordinated by the main applicant (Mef Nilbert) and are built on collaborative efforts within a multiprofessional environment hosting epidemiologists, basic scientists, bioinformaticians, biostatisticians, pathologists, surgeons, oncologists and researchers in training.
Short titlePrecision Medicine in Hereditary Cancer and Sarcoma
StatusNot started

Participants

Related research output

Rohlin, A., Rambech, E., Anders Kvist, Therese Törngren, Eiengård, F., Lundstam, U., Zagoras, T., Samuel Gebre-Medhin, Åke Borg, Björk, J., Mef Nilbert & Nordling, M., 2017 Apr, In : Familial Cancer. 16, 2, p. 195-203

Research output: Contribution to journalArticle

Lagerstedt-Robinson, K., Rohlin, A., Aravidis, C., Melin, B., Nordling, M., Stenmark-Askmalm, M., Lindblom, A. & Mef Nilbert, 2016 Nov 1, In : Oncology Reports. 36, 5, p. 2823-2835 13 p.

Research output: Contribution to journalArticle

Fredrik Liedberg, Ulf Gerdtham, Gralén, K., Gudjonsson, S., Jahnson, S., Johansson, I., Oskar Hagberg, Larsson, S., Lind, A. K., Löfgren, A., Wanegård, J., Åberg, H. & Mef Nilbert, 2016, In : British Journal of Cancer. 115, p. 770-775

Research output: Contribution to journalArticle

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