Regulation of pro-inflammatory cytokine expression in periodontal ligament cells

Research areas and keywords

UKÄ subject classification

Medical and Health Sciences

Description

We have demonstrated that human periodontal ligament cells not only produce collagen but also may act as immune cells. Thus, not only white blood cells but also tissue-cells contibute to cytokine production in periodontal inflammation. This project aims to elucidate the mechanisms explaining the phenotype-shift and identify pathways regulating the functional properties of periodontal ligament cells.

Status	Active
Effective start/end date	2015/08/03 → …

Participants

Bengt-Olof Nilsson - Department of Experimental Medical Science - Vascular Physiology (PI)
Daniel Svensson - Vascular Physiology (Research student)
Nebel, Daniel - Vascular Physiology (Researcher)
Alexandra Aidoukovitch - Vascular Physiology (Research student)

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Related research output

1α,25-dihydroxyvitamin D3 promotes osteogenic activity and downregulates proinflammatory cytokine expression in human periodontal ligament cells.

Nebel, D., Daniel Svensson, Arosenius, K., Larsson, E., Daniel Jönsson & Bengt-Olof Nilsson, 2015, In : Journal of Periodontal Research. 50, 5, p. 666-673

Research output: Contribution to journal › Article

Differential effects of LPS from Escherichia coli and Porphyromonas gingivalis on IL-6 production in human periodontal ligament cells.

Nebel, D., Arvidsson, J., Lillqvist, J., Holm, A. & Bengt-Olof Nilsson, 2013, In : Acta Odontologica Scandinavica. 71, 3-4, p. 892-898

Research output: Contribution to journal › Article

The human periodontal ligament cell: a fibroblast-like cell acting as an immune cell.

Daniel Jönsson, Nebel, D., Bratthall, G. & Bengt-Olof Nilsson, 2011, In : Journal of Periodontal Research. 46, p. 153-157

Research output: Contribution to journal › Article

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