Scaffolds and mesenchymal stem cells to treat lung disease

Project: Research

Description

The airways are challenged by a large amount of environmental stress every day, such as various microbes and pollutants which can result in fibrosis and/or emphysema. This is a trait seen in several chronic respiratory diseases, i.e. asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and bronchiolitis obliterans syndrome. The effectiveness of current treatments is limited to decrease symptoms and delay disease progression.

Our long-term vision is to regenerate functional human lung tissue in vivo. The goal of this project is to increase the knowledge of the pathophysiological mechanisms behind serious life-shortening chronic lung diseases and to identify therapeutic cells and/or matrix molecules for future therapy.

To reach our goal we focus on three main areas
1) Characterization of the molecular structure of the extracellular matrix (ECM) in health and disease.
2) Cells with regenerative capacity of importance for the lung niche.
3) Develop model systems to study the interplay between the ECM and cells and how these generate tissue regeneration.
StatusActive
Effective start/end date2014/01/012019/12/31

Participants