The Extracellular Matrix in Patients with CF or COPD as a Basis for Novel Therapeutical Opportunities
Recurrent bacterial infections in the lung of patients is a significant problem for patients with chronic obstructive pulmonary disease (COPD) or cystic fibrosis (CF), and a common cause of contact with health care professionals. Unfortunately, antimicrobial resistance is an emerging and serious threat to the health of these patients and there is an urgent need for novel therapies against Pseudomonas aeruginosa, a relatively common Gram-negative bacterial species. This research project aims at defining target molecules, both within the host proteome and on bacteria, that will lead to new strategies for intervention.
|Effective start/end date||2018/01/01 → 2025/12/31|
Related research output
Bacterial outer membrane vesicles induce vitronectin release into the bronchoalveolar space conferring protection from complement-mediated killingMagnus Paulsson, Che, K. F., Jonas Ahl, Johan Tham, Sandblad, L., Smith, M. E., Qvarfordt, I., Yu Ching Su, Lindén, A. & Kristian Riesbeck, 2018 Jul 13, In : Frontiers in Microbiology. 9, JUL, 1559.
Research output: Contribution to journal › Article
Vitronectin is produced in the lung upon infection by respiratory pathogens, and is utilized to evade the innate immunityMagnus Paulsson, Che, K. F., Jonas Ahl, Smith, M. E., Qvarfordt, I., Yu-Ching Su, Linden, A. & Kristian Riesbeck, 2017 Sep 5, p. P132.
Research output: Contribution to conference › Poster