The Virulence and Infection Mechanisms of Helicobacter pylori in the Human Gastric Mucosa

Project: Research


Helicobacter pylori infects more than half of the human population and is significantly correlated to cancer progression. The Riesbeck research team has an ultimate goal to define new antimicrobial treatment strategies against H. pylori through a well-designed study of novel virulence mechanisms of this gastric pathogen. We use various high-ended techniques, sophisticated strategies and state-of-the-art technology to define H. pylori surface-exposed virulence factors that confer the previously undescribed opportunistic interactions of H. pylori with the host immune system (i.e. during inflammation that results in degradation of the extracellular matrix and cancer progression). It is also within the research scope of our team to decipher the biosynthesis and membrane biochemistry of H. pylori outer membrane vesicles, and novel roles for virulence of these outer membrane vesicles. We expect that findings from our research will result in important and significant positive outcome for the development of more effective novel treatment strategies to prevent gastric mucosal colonization by H. pylori and in the long-term reduction of cancer progression. The new knowledge garnered will be used as an innovative anti-infective therapy targeting H. pylori.
Effective start/end date2019/01/012026/12/31