γ 2‐MSH increases during graded exercise in healthy subjects: comparison with plasma catecholamines, neuropeptides, aldosterone and renin activity

Research output: Contribution to journalArticle

Abstract

Summary. To evaluate the possibility that the proopiomelanocortin (POMC)‐derived peptide γ2‐melanocyte stimulating hormone (γ2‐MSH) has a role in circulatory regulation in man we studied circulating levels of this peptide at three different stages of physical activity in 10 young healthy subjects. The results were compared to simultaneously measured plasma levels of catecholamines, neuropeptide Y, vasopressin, renin activity, aldosterone and human α‐atrial natriuretic peptide (α‐hANP) and of the vasodilatory peptides calcitonin gene‐related peptide, substance P and vasoactive intestinal peptide. The plasma levels of γ2‐MSH‐LI (like immunoreactivity) increased from 1009 ± 101 pmol 1‐1 at supine rest to 1281 ± 79 pmol 1‐1 when measured after 10 min walking (P<0·05), and remained at this increased level also after a consecutive further increase of physical activity (4 min stair rush), 1293 ± 87 pmol 1‐1 (P<0·05 vs. at rest). The increase in circulating γ2‐MSH‐LI levels preceded the elevation of the venous plasma noradrenaline level, but did not rise further with more pronounced activation of the sympathetic nervous system at the highest grade of physical activity examined.

Details

Authors
External organisations
  • Skåne University Hospital
  • St. Lars Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Physiology

Keywords

  • atrial natriuretic peptide, blood pressure regulation, calcitonin gene‐related peptide, neuropeptide Y, physical exercise, substance P, vasopressin
Original languageEnglish
Pages (from-to)321-327
Number of pages7
JournalClinical Physiology
Volume10
Issue number4
Publication statusPublished - 1990 Jan 1
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes