17 beta-estradiol expands IgA-Producing b cells in mice deficient for the mu chain

Research output: Contribution to journalArticle

Abstract

Oestrogen is not only a sex hormone but also an important regulator of the immune system. Expression of the heavy chain of IgM (mu) is essential for B-cell differentiation. However, a small number of IgA-positive B cells can be found in mice lacking the mu chain (mu MT-/-). The aim of this study was to investigate the effects of oestrogen on this alternative B-cell pathway in mu MT-/- mice. Our results clearly demonstrate that oestrogen increases the frequency of IgA-producing B cells in mu MT-/- mice in both bone marrow and spleen cells. We also show that mature IgM-producing B cells are not required for oestrogen-mediated suppression of granulocyte-mediated inflammation or thymic involution. In conclusion, we demonstrate that 17 beta-estradiol benzoate increases the frequency of IgA-producing B cells in mu MT-/- mice, suggesting that oestrogen can influence the alternative B-cell pathway found in mu MT-/- mice.

Details

Authors
  • M. K. Lagerquist
  • M. C. Erlandsson
  • U. Islander
  • L. Svensson
  • Rikard Holmdahl
  • H. Carlsten
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Immunology in the medical area
Original languageEnglish
Pages (from-to)12-17
JournalScandinavian Journal of Immunology
Volume67
Issue number1
Publication statusPublished - 2008
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)