2-deoxy-2-[F-18]fluoro-D-glucose uptake and correlation to intratumoral heterogeneity

Research output: Contribution to journalArticle

Abstract

The aim of this study was to investigate the pattern of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) uptake in relation to the intratumoral histopathological appearance. Materials and Methods: Intratumoral distribution of FDG in nude mice with xenografted tumours originating from an established head and neck squamous cell carcinoma was studied. FDG uptake and the con-elation to histopathological appearance was evaluated in four separate quarters of each tumour. Results: Variations in FDG uptake correlating to the presence of tumour cells was demonstrated. Quarters containing more than 50% tumour cells showed a significantly higher FDG uptake (p=0.028) than quarters with more stromal tissue and necrosis. Conclusion: This Study shows that the heterogenic FDG uptake within a tumour correlates to histopathological findings and that the variable appearance of tracer uptake on the PET scan depends on distribution of different tissue components in the tumour. This intratumoral heterogeneity calls for caution when evaluating a PET scan where median values of larger areas will be misguiding and thus small areas with high uptake should be regarded as the regions of interest.

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Authors
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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • squamous cell carcinoma, 2-deoxy-2-[F-18]fluoro-D-glucose, positron emission tomography, head, and neck, intratumoral heterogeneity, xenograft
Original languageEnglish
Pages (from-to)2155-2159
JournalAnticancer research
Volume27
Issue number4B
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Oncology, MV (013035000), Otorhinolaryngology (Lund) (013044000), Oto-Rhino-Laryngology (013243500), Reconstructive Surgery (013240300), Division V (013230900)

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