3,4-dideoxyglucosone-3-ene in peritoneal dialysis fluids infused into the peritoneal cavity cannot be found in plasma.

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Glucose degradation products (GDPs) are important for the outcome of peritoneal dialysis (PD) treatment. The most cytotoxic GDP found in conventionally manufactured fluids, 3,4-dideoxyglucosone-3-ene (3,4-DGE), may in addition be recruited from 3-deoxyglucosone (3-DG). What happens with the GDPs in the fluid infused into patients during PD is not known. We investigated whether 3,4-DGE and 3-DG in PD fluid can be found in plasma during treatment. DESIGN: Patients on PD were dialyzed with a conventional PD fluid containing 43 micromol/L 3,4-DGE and 281 micromol/L 3-DG. Parallel experiments were performed in rats and in vitro with human plasma. The rats were dialyzed with a PD fluid containing 100 micromol/L 3,4-DGE and 200 micromol/L 3-DG. RESULTS: The 3,4-DGE concentration in the peritoneum declined at a much higher rate during the dwell than did the 3-DG concentration. However, 3,4-DGE was not detected in the plasma of patients or of rats during dialysis. The 3-DG concentration in plasma peaked shortly after infusion of fluid into the peritoneal cavity. The 3,4-DGE concentration during experimental incubation in plasma declined rapidly; the 3-DG concentration declined only 10% as rapidly (or less). CONCLUSION: During dialysis, 3,4-DGE could not be detected in plasma of either PD patients or rats, presumably because of its high reactivity. On the other hand, 3-DG may pass through the membrane and be detected in the blood.

Details

Authors
  • Martin Erixon
  • Anders Wieslander
  • Torbjörn Lindén
  • Ola Carlsson
  • Jan Åke Jönsson
  • Ole Simonsen
  • Per Kjellstrand
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Urology and Nephrology

Keywords

  • Peritoneal dialysis fluid, glucose degradation products, 3, 3-DG, 4-DGE, plasma, advanced glycation end-products
Original languageEnglish
Pages (from-to)S28-S31
JournalPeritoneal Dialysis International
Volume29 Suppl 2
Publication statusPublished - 2009
Publication categoryResearch
Peer-reviewedYes
Event12th Congress of the International-Society-for-Peritoneal-Dialysis - Istanbul, TURKEY
Duration: 2008 Jun 202008 Jun 24

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Nephrology (013230024), Analytical Chemistry (S/LTH) (011001004)