3D biomaterial models of human brain disease

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3D biomaterial models of human brain disease. / Kajtez, Janko; Nilsson, Fredrik; Fiorenzano, Alessandro; Parmar, Malin; Emnéus, Jenny.

In: Neurochemistry International, Vol. 147, 105043, 2021.

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TY - JOUR

T1 - 3D biomaterial models of human brain disease

AU - Kajtez, Janko

AU - Nilsson, Fredrik

AU - Fiorenzano, Alessandro

AU - Parmar, Malin

AU - Emnéus, Jenny

N1 - Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

PY - 2021

Y1 - 2021

N2 - Inherent limitations of the traditional approaches to study brain function and disease, such as rodent models and 2D cell culture platforms, have led to the development of 3D in vitro cell culture systems. These systems, products of multidisciplinary efforts encompassing stem cell biology, materials engineering, and biofabrication, have quickly shown great potential to mimic biochemical composition, structural properties, and cellular morphology and diversity found in the native brain tissue. Crucial to these developments have been the advancements in stem cell technology and cell reprogramming protocols that allow reproducible generation of human subtype-specific neurons and glia in laboratory conditions. At the same time, biomaterials have been designed to provide cells in 3D with a microenvironment that mimics functional and structural aspects of the native extracellular matrix with increasing fidelity. In this article, we review the use of biomaterials in 3D in vitro models of neurological disorders with focus on hydrogel technology and with biochemical composition and physical properties of the in vivo environment as reference.

AB - Inherent limitations of the traditional approaches to study brain function and disease, such as rodent models and 2D cell culture platforms, have led to the development of 3D in vitro cell culture systems. These systems, products of multidisciplinary efforts encompassing stem cell biology, materials engineering, and biofabrication, have quickly shown great potential to mimic biochemical composition, structural properties, and cellular morphology and diversity found in the native brain tissue. Crucial to these developments have been the advancements in stem cell technology and cell reprogramming protocols that allow reproducible generation of human subtype-specific neurons and glia in laboratory conditions. At the same time, biomaterials have been designed to provide cells in 3D with a microenvironment that mimics functional and structural aspects of the native extracellular matrix with increasing fidelity. In this article, we review the use of biomaterials in 3D in vitro models of neurological disorders with focus on hydrogel technology and with biochemical composition and physical properties of the in vivo environment as reference.

U2 - 10.1016/j.neuint.2021.105043

DO - 10.1016/j.neuint.2021.105043

M3 - Article

C2 - 33887378

VL - 147

JO - Neurochemistry International

JF - Neurochemistry International

SN - 0197-0186

M1 - 105043

ER -