3-Hydroxy fatty acids in saliva as diagnostic markers in chronic periodontitis

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Abstract

Saturated straight- and branched-chain 3-hydroxy fatty acids (3-OH FAs) of 10-18 carbon chain lengths were determined in saliva from 27 individuals with chronic periodontitis and 18 healthy individuals by using gas chromatography-tandem mass spectrometry. Of the 14 different 3-OH FAs detected, 3-OH-C-i17:0 was the most abundant in the periodontitis samples while 3-OH-C-14:0 was the most abundant in the healthy individuals. Considering the relative percentages of 3-OH-C-12:0, 3-OH-C-14:0, 3OH-C-i17:0, and 3-OH-C-17:0, 95.6% of all cases were correctly classified as healthy individuals or periodontitis patients by means of discriminant analysis. The sensitivity, specificity, positive predictive value and negative predictive value of 3-OH FA analysis in diagnosing peridontitis were, respectively, 0.92, 1.00, 1.00, and 0.90. The results indicate that 3-OH FA analysis of saliva samples is a useful diagnostic method in chronic periodontitis.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Microbiology in the medical area

Keywords

  • gas chronnatography-mass spectrometry, acids, anaerobic gram-negative bacteria/periodontal pathogens, 3-hydroxy fatty, periodontitis/etiology, microbial chemical, inarkers
Original languageEnglish
Pages (from-to)285-291
JournalJournal of Microbiological Methods
Volume62
Issue number3
Publication statusPublished - 2005
Publication categoryResearch
Peer-reviewedYes