5 ' flanking variants of resistin are associated with obesity

Research output: Contribution to journalArticle


title = "5 ' flanking variants of resistin are associated with obesity",
abstract = "Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into the association of these SNPs with diabetes and obesity revealed two 5' flanking variants (g.-537 and g.-420), in strong linkage disequilibrium, that are associated with BMI. In nondiabetic individuals from the Quebec City area and the Saguenay-Lac-St-Jean region of Quebec, the g.-537 mutation (allelic frequency = 0.04) was significantly associated with an increase in BMI (P = 0.03 and P = 0.01, respectively). When the data from these two populations were combined and adjusted for age and sex, both the g.-537 (odds ratio [OR] 2.72, 95{\%} Cl 1.28-5.81) and the g.-420 variants (1.58, 1.06-2.35) were associated with an increased risk for a BMI greater than or equal to30 kg/m(2). In contrast, in case/control and family-based study populations from Scandinavia, we saw no effect on BMI with either of these promoter variants. No association was seen with diabetes in any of the population samples.",
author = "JC Engert and MC Vohl and SM Williams and P Lepage and JC Loredo-Osti and J Faith and C Dore and Y Renaud and NP Burtt and A Villeneuve and JN Hirschhorn and D Altshuler and Leif Groop and JP Despres and D Gaudet and TJ Hudson",
year = "2002",
doi = "10.2337/diabetes.51.5.1629",
language = "English",
volume = "51",
pages = "1629--1634",
journal = "Diabetes",
issn = "1939-327X",
publisher = "American Diabetes Association Inc.",
number = "5",