5 ' flanking variants of resistin are associated with obesity

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5 ' flanking variants of resistin are associated with obesity. / Engert, JC; Vohl, MC; Williams, SM; Lepage, P; Loredo-Osti, JC; Faith, J; Dore, C; Renaud, Y; Burtt, NP; Villeneuve, A; Hirschhorn, JN; Altshuler, D; Groop, Leif; Despres, JP; Gaudet, D; Hudson, TJ.

In: Diabetes, Vol. 51, No. 5, 2002, p. 1629-1634.

Research output: Contribution to journalArticle

Harvard

Engert, JC, Vohl, MC, Williams, SM, Lepage, P, Loredo-Osti, JC, Faith, J, Dore, C, Renaud, Y, Burtt, NP, Villeneuve, A, Hirschhorn, JN, Altshuler, D, Groop, L, Despres, JP, Gaudet, D & Hudson, TJ 2002, '5 ' flanking variants of resistin are associated with obesity', Diabetes, vol. 51, no. 5, pp. 1629-1634. https://doi.org/10.2337/diabetes.51.5.1629

APA

Engert, JC., Vohl, MC., Williams, SM., Lepage, P., Loredo-Osti, JC., Faith, J., ... Hudson, TJ. (2002). 5 ' flanking variants of resistin are associated with obesity. Diabetes, 51(5), 1629-1634. https://doi.org/10.2337/diabetes.51.5.1629

CBE

Engert JC, Vohl MC, Williams SM, Lepage P, Loredo-Osti JC, Faith J, Dore C, Renaud Y, Burtt NP, Villeneuve A, Hirschhorn JN, Altshuler D, Groop L, Despres JP, Gaudet D, Hudson TJ. 2002. 5 ' flanking variants of resistin are associated with obesity. Diabetes. 51(5):1629-1634. https://doi.org/10.2337/diabetes.51.5.1629

MLA

Vancouver

Engert JC, Vohl MC, Williams SM, Lepage P, Loredo-Osti JC, Faith J et al. 5 ' flanking variants of resistin are associated with obesity. Diabetes. 2002;51(5):1629-1634. https://doi.org/10.2337/diabetes.51.5.1629

Author

Engert, JC ; Vohl, MC ; Williams, SM ; Lepage, P ; Loredo-Osti, JC ; Faith, J ; Dore, C ; Renaud, Y ; Burtt, NP ; Villeneuve, A ; Hirschhorn, JN ; Altshuler, D ; Groop, Leif ; Despres, JP ; Gaudet, D ; Hudson, TJ. / 5 ' flanking variants of resistin are associated with obesity. In: Diabetes. 2002 ; Vol. 51, No. 5. pp. 1629-1634.

RIS

TY - JOUR

T1 - 5 ' flanking variants of resistin are associated with obesity

AU - Engert, JC

AU - Vohl, MC

AU - Williams, SM

AU - Lepage, P

AU - Loredo-Osti, JC

AU - Faith, J

AU - Dore, C

AU - Renaud, Y

AU - Burtt, NP

AU - Villeneuve, A

AU - Hirschhorn, JN

AU - Altshuler, D

AU - Groop, Leif

AU - Despres, JP

AU - Gaudet, D

AU - Hudson, TJ

PY - 2002

Y1 - 2002

N2 - Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into the association of these SNPs with diabetes and obesity revealed two 5' flanking variants (g.-537 and g.-420), in strong linkage disequilibrium, that are associated with BMI. In nondiabetic individuals from the Quebec City area and the Saguenay-Lac-St-Jean region of Quebec, the g.-537 mutation (allelic frequency = 0.04) was significantly associated with an increase in BMI (P = 0.03 and P = 0.01, respectively). When the data from these two populations were combined and adjusted for age and sex, both the g.-537 (odds ratio [OR] 2.72, 95% Cl 1.28-5.81) and the g.-420 variants (1.58, 1.06-2.35) were associated with an increased risk for a BMI greater than or equal to30 kg/m(2). In contrast, in case/control and family-based study populations from Scandinavia, we saw no effect on BMI with either of these promoter variants. No association was seen with diabetes in any of the population samples.

AB - Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into the association of these SNPs with diabetes and obesity revealed two 5' flanking variants (g.-537 and g.-420), in strong linkage disequilibrium, that are associated with BMI. In nondiabetic individuals from the Quebec City area and the Saguenay-Lac-St-Jean region of Quebec, the g.-537 mutation (allelic frequency = 0.04) was significantly associated with an increase in BMI (P = 0.03 and P = 0.01, respectively). When the data from these two populations were combined and adjusted for age and sex, both the g.-537 (odds ratio [OR] 2.72, 95% Cl 1.28-5.81) and the g.-420 variants (1.58, 1.06-2.35) were associated with an increased risk for a BMI greater than or equal to30 kg/m(2). In contrast, in case/control and family-based study populations from Scandinavia, we saw no effect on BMI with either of these promoter variants. No association was seen with diabetes in any of the population samples.

U2 - 10.2337/diabetes.51.5.1629

DO - 10.2337/diabetes.51.5.1629

M3 - Article

VL - 51

SP - 1629

EP - 1634

JO - Diabetes

JF - Diabetes

SN - 1939-327X

IS - 5

ER -