5-Hydroxytryptamine stimulates the formation of inositol phosphate in astrocytes from different regions of the brain

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Abstract

5-Hydroxytryptamine (5-HT) stimulated the turnover of phosphoinositide in primary cultures of astroglia from the cerebral cortex, striatum, hippocampus and brain stem. Ketanserin and ritanserin, selective antagonists for the central 5-HT2 receptor, inhibited the 5-HT-stimulated formation of inositol monophosphate. In contrast, there was no statistically significant accumulation of cyclic AMP after incubation with different concentrations of 5-HT in any of the cultures studied. The results indicate that astrocytes from various regions of the brain possess 5-HT2 receptors coupled to the formation of inositol phosphates.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pharmacology and Toxicology

Keywords

  • brain stem, hippocampus, striatum, second messenger, astroglial primary culture, cerebral cortex, diacylglycerol, inositol trisphosphate, 5-HT2-receptor
Original languageEnglish
Pages (from-to)1377-1382
JournalNeuropharmacology
Volume26
Issue number9
Publication statusPublished - 1987
Publication categoryResearch
Peer-reviewedYes