5-Hydroxytryptamine stimulates the formation of inositol phosphate in astrocytes from different regions of the brain

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5-Hydroxytryptamine stimulates the formation of inositol phosphate in astrocytes from different regions of the brain. / Hansson, Elisabeth; Simonsson, Per; Alling, Christer.

In: Neuropharmacology, Vol. 26, No. 9, 1987, p. 1377-1382.

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T1 - 5-Hydroxytryptamine stimulates the formation of inositol phosphate in astrocytes from different regions of the brain

AU - Hansson, Elisabeth

AU - Simonsson, Per

AU - Alling, Christer

PY - 1987

Y1 - 1987

N2 - 5-Hydroxytryptamine (5-HT) stimulated the turnover of phosphoinositide in primary cultures of astroglia from the cerebral cortex, striatum, hippocampus and brain stem. Ketanserin and ritanserin, selective antagonists for the central 5-HT2 receptor, inhibited the 5-HT-stimulated formation of inositol monophosphate. In contrast, there was no statistically significant accumulation of cyclic AMP after incubation with different concentrations of 5-HT in any of the cultures studied. The results indicate that astrocytes from various regions of the brain possess 5-HT2 receptors coupled to the formation of inositol phosphates.

AB - 5-Hydroxytryptamine (5-HT) stimulated the turnover of phosphoinositide in primary cultures of astroglia from the cerebral cortex, striatum, hippocampus and brain stem. Ketanserin and ritanserin, selective antagonists for the central 5-HT2 receptor, inhibited the 5-HT-stimulated formation of inositol monophosphate. In contrast, there was no statistically significant accumulation of cyclic AMP after incubation with different concentrations of 5-HT in any of the cultures studied. The results indicate that astrocytes from various regions of the brain possess 5-HT2 receptors coupled to the formation of inositol phosphates.

KW - brain stem

KW - hippocampus

KW - striatum

KW - second messenger

KW - astroglial primary culture

KW - cerebral cortex

KW - diacylglycerol

KW - inositol trisphosphate

KW - 5-HT2-receptor

U2 - 10.1016/0028-3908(87)90102-X

DO - 10.1016/0028-3908(87)90102-X

M3 - Article

VL - 26

SP - 1377

EP - 1382

JO - Neuropharmacology

JF - Neuropharmacology

SN - 1873-7064

IS - 9

ER -