A circular RNA generated from an intron of the insulin gene controls insulin secretion

Research output: Contribution to journalArticle


title = "A circular RNA generated from an intron of the insulin gene controls insulin secretion",
abstract = "Fine-tuning of insulin release from pancreatic β-cells is essential to maintain blood glucose homeostasis. Here, we report that insulin secretion is regulated by a circular RNA containing the lariat sequence of the second intron of the insulin gene. Silencing of this intronic circular RNA in pancreatic islets leads to a decrease in the expression of key components of the secretory machinery of β-cells, resulting in impaired glucose- or KCl-induced insulin release and calcium signaling. The effect of the circular RNA is exerted at the transcriptional level and involves an interaction with the RNA-binding protein TAR DNA-binding protein 43 kDa (TDP-43). The level of this circularized intron is reduced in the islets of rodent diabetes models and of type 2 diabetic patients, possibly explaining their impaired secretory capacity. The study of this and other circular RNAs helps understanding β-cell dysfunction under diabetes conditions, and the etiology of this common metabolic disorder.",
author = "Lisa Stoll and Adriana Rodr{\'i}guez-Trejo and Claudiane Guay and Flora Brozzi and Bayazit, {Mustafa Bilal} and Sonia Gattesco and V{\'e}ronique Menoud and Jonathan Sobel and Marques, {Ana Claudia} and Ven{\o}, {Morten Trillingsgaard} and Esguerra, {Jonathan Lou S.} and Mohammad Barghouth and Mara Suleiman and Lorella Marselli and J{\o}rgen Kjems and Lena Eliasson and Erik Renstr{\"o}m and Karim Bouzakri and Michel Pinget and Piero Marchetti and Romano Regazzi",
year = "2020",
doi = "10.1038/s41467-020-19381-w",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",