A click approach to unprotected glycodendrimers

Research output: Contribution to journalArticle

Abstract

Click chemistry in combination with ultrafiltration has allowed the quick, efficient, and reliable multivalent conjugation of unprotected alkyne-derived carbohydrates to three generations of azido-terminated gallic acid-triethylene glycol dendrimers under aqueous conditions. The reported procedure allows the atom economical incorporation of up to 27 unprotected fucose, mannose, and lactose residues, in reproducible high yields (up to 92%), requiring only catalytic amounts of Cu. The completion of the conjugation process was clearly established in all cases by both 1H NMR and MALDI-TOF MS.

Details

Authors
  • Eduardo Fernandez-Megia
  • Juan Correa
  • Irene Rodríguez-Meizoso
  • Ricardo Riguera
External organisations
  • CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN)
  • University of Santiago de Compostela
Original languageEnglish
Pages (from-to)2113-2120
Number of pages8
JournalMacromolecules
Volume39
Issue number6
Publication statusPublished - 2006 Mar 21
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes