A critical evaluation of wet biomarkers for huntington's disease: Current status and ways forward

Research output: Contribution to journalReview article

Abstract

There is an unmet clinical need for objective biomarkers to monitor disease progression and treatment response in Huntington's disease (HD). The aim of this review is, therefore, to provide practical advice for biomarker discovery and to summarise studies on biofluid markers for HD. A PubMed search was performed to review literature with regard to candidate saliva, urine, blood and cerebrospinal fluid biomarkers for HD. Information has been organised into tables to allow a pragmatic approach to the discussion of the evidence and generation of practical recommendations for future studies. Many of the markers published converge on metabolic and inflammatory pathways, although changes in other analytes representing antioxidant and growth factor pathways have also been found. The most promising markers reflect neuronal and glial degeneration, particularly neurofilament light chain. International collaboration to standardise assays and study protocols, as well as to recruit sufficiently large cohorts, will facilitate future biomarker discovery and development.

Details

Authors
Organisations
External organisations
  • University of Manchester
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • biomarker, blood, cerebrospinal fluid, Huntington's disease, plasma, saliva, serum, urine
Original languageEnglish
Pages (from-to)109-135
Number of pages27
JournalJournal of Huntington's disease
Volume7
Issue number2
Publication statusPublished - 2018 Jan 1
Publication categoryResearch
Peer-reviewedYes