A cross-sectional magnetic resonance imaging study of factors influencing growth plate closure in adolescents and young adults

Research output: Contribution to journalArticle

Abstract

Aim: To assess growth plate fusion by magnetic resonance imaging (MRI) and evaluate the correlation with sex, age, pubertal development, physical activity and BMI. Methods: Wrist, knee and ankle of 958 healthy subjects aged 14.0-21.5 years old were examined using MRI and graded by two radiologists. Correlations of growth plate fusion score with age, pubertal development, physical activity and BMI were assessed. Results: Complete growth plate fusion occurred in 75%, 85%, 97%, 98%, 98% and 90%, 97%, 95%, 97%, 98% (radius, femur, proximal- and distal tibia and calcaneus) in 17-year-old females and 19-year-old males, respectively. Complete fusion occurs approximately 2 years earlier in girls than in boys. Pubertal development correlated with growth plate fusion score (ρ = 0.514-0.598 for the different growth plate sites) but regular physical activity did not. BMI also correlated with growth plate fusion (ρ = 0.186-0.384). Stratified logistic regression showed increased odds ratio (OR F: 2.65-8.71; M: 1.71-4.03) for growth plate fusion of obese or overweight subects versus normal-weight subjects. Inter-observer agreement was high (Κ = 0.87-0.94). Conclusion: Growth plate fusion can be assessed by MRI; occurs in an ascending order, from the foot to the wrist; and is significantly influenced by sex, pubertal development and BMI, but not by physical activity.

Details

Authors
  • Ola Kvist
  • Ana Luiza Dallora
  • Ola Nilsson
  • Peter Anderberg
  • Johan Sanmartin Berglund
  • Carl Erik Flodmark
  • Sandra Diaz
Organisations
External organisations
  • Karolinska University Hospital
  • Karolinska Institutet
  • Blekinge Institute of Technology
  • Örebro University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Radiology, Nuclear Medicine and Medical Imaging
  • Pediatrics

Keywords

  • growth plate, magnetic resonance imaging, maturation process, obesity, puberty
Original languageEnglish
Pages (from-to)1249-1256
JournalActa Paediatrica, International Journal of Paediatrics
Volume110
Issue number4
Early online date2020 Oct 12
Publication statusPublished - 2021
Publication categoryResearch
Peer-reviewedYes