A cross-sectional magnetic resonance imaging study of factors influencing growth plate closure in adolescents and young adults

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@article{bfd434934a48403f91c8b3032878850d,
title = "A cross-sectional magnetic resonance imaging study of factors influencing growth plate closure in adolescents and young adults",
abstract = "Aim: To assess growth plate fusion by magnetic resonance imaging (MRI) and evaluate the correlation with sex, age, pubertal development, physical activity and BMI. Methods: Wrist, knee and ankle of 958 healthy subjects aged 14.0-21.5 years old were examined using MRI and graded by two radiologists. Correlations of growth plate fusion score with age, pubertal development, physical activity and BMI were assessed. Results: Complete growth plate fusion occurred in 75%, 85%, 97%, 98%, 98% and 90%, 97%, 95%, 97%, 98% (radius, femur, proximal- and distal tibia and calcaneus) in 17-year-old females and 19-year-old males, respectively. Complete fusion occurs approximately 2 years earlier in girls than in boys. Pubertal development correlated with growth plate fusion score (ρ = 0.514-0.598 for the different growth plate sites) but regular physical activity did not. BMI also correlated with growth plate fusion (ρ = 0.186-0.384). Stratified logistic regression showed increased odds ratio (OR F: 2.65-8.71; M: 1.71-4.03) for growth plate fusion of obese or overweight subects versus normal-weight subjects. Inter-observer agreement was high (Κ = 0.87-0.94). Conclusion: Growth plate fusion can be assessed by MRI; occurs in an ascending order, from the foot to the wrist; and is significantly influenced by sex, pubertal development and BMI, but not by physical activity.",
keywords = "growth plate, magnetic resonance imaging, maturation process, obesity, puberty",
author = "Ola Kvist and {Luiza Dallora}, Ana and Ola Nilsson and Peter Anderberg and {Sanmartin Berglund}, Johan and Flodmark, {Carl Erik} and Sandra Diaz",
year = "2021",
doi = "10.1111/apa.15617",
language = "English",
volume = "110",
pages = "1249--1256",
journal = "Acta P{\ae}diatrica",
issn = "1651-2227",
publisher = "Wiley-Blackwell",
number = "4",

}