A cross-sectional magnetic resonance imaging study of factors influencing growth plate closure in adolescents and young adults

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A cross-sectional magnetic resonance imaging study of factors influencing growth plate closure in adolescents and young adults. / Kvist, Ola; Luiza Dallora, Ana; Nilsson, Ola; Anderberg, Peter; Sanmartin Berglund, Johan; Flodmark, Carl Erik; Diaz, Sandra.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 110, No. 4, 2021, p. 1249-1256.

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Kvist, Ola ; Luiza Dallora, Ana ; Nilsson, Ola ; Anderberg, Peter ; Sanmartin Berglund, Johan ; Flodmark, Carl Erik ; Diaz, Sandra. / A cross-sectional magnetic resonance imaging study of factors influencing growth plate closure in adolescents and young adults. In: Acta Paediatrica, International Journal of Paediatrics. 2021 ; Vol. 110, No. 4. pp. 1249-1256.

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TY - JOUR

T1 - A cross-sectional magnetic resonance imaging study of factors influencing growth plate closure in adolescents and young adults

AU - Kvist, Ola

AU - Luiza Dallora, Ana

AU - Nilsson, Ola

AU - Anderberg, Peter

AU - Sanmartin Berglund, Johan

AU - Flodmark, Carl Erik

AU - Diaz, Sandra

PY - 2021

Y1 - 2021

N2 - Aim: To assess growth plate fusion by magnetic resonance imaging (MRI) and evaluate the correlation with sex, age, pubertal development, physical activity and BMI. Methods: Wrist, knee and ankle of 958 healthy subjects aged 14.0-21.5 years old were examined using MRI and graded by two radiologists. Correlations of growth plate fusion score with age, pubertal development, physical activity and BMI were assessed. Results: Complete growth plate fusion occurred in 75%, 85%, 97%, 98%, 98% and 90%, 97%, 95%, 97%, 98% (radius, femur, proximal- and distal tibia and calcaneus) in 17-year-old females and 19-year-old males, respectively. Complete fusion occurs approximately 2 years earlier in girls than in boys. Pubertal development correlated with growth plate fusion score (ρ = 0.514-0.598 for the different growth plate sites) but regular physical activity did not. BMI also correlated with growth plate fusion (ρ = 0.186-0.384). Stratified logistic regression showed increased odds ratio (OR F: 2.65-8.71; M: 1.71-4.03) for growth plate fusion of obese or overweight subects versus normal-weight subjects. Inter-observer agreement was high (Κ = 0.87-0.94). Conclusion: Growth plate fusion can be assessed by MRI; occurs in an ascending order, from the foot to the wrist; and is significantly influenced by sex, pubertal development and BMI, but not by physical activity.

AB - Aim: To assess growth plate fusion by magnetic resonance imaging (MRI) and evaluate the correlation with sex, age, pubertal development, physical activity and BMI. Methods: Wrist, knee and ankle of 958 healthy subjects aged 14.0-21.5 years old were examined using MRI and graded by two radiologists. Correlations of growth plate fusion score with age, pubertal development, physical activity and BMI were assessed. Results: Complete growth plate fusion occurred in 75%, 85%, 97%, 98%, 98% and 90%, 97%, 95%, 97%, 98% (radius, femur, proximal- and distal tibia and calcaneus) in 17-year-old females and 19-year-old males, respectively. Complete fusion occurs approximately 2 years earlier in girls than in boys. Pubertal development correlated with growth plate fusion score (ρ = 0.514-0.598 for the different growth plate sites) but regular physical activity did not. BMI also correlated with growth plate fusion (ρ = 0.186-0.384). Stratified logistic regression showed increased odds ratio (OR F: 2.65-8.71; M: 1.71-4.03) for growth plate fusion of obese or overweight subects versus normal-weight subjects. Inter-observer agreement was high (Κ = 0.87-0.94). Conclusion: Growth plate fusion can be assessed by MRI; occurs in an ascending order, from the foot to the wrist; and is significantly influenced by sex, pubertal development and BMI, but not by physical activity.

KW - growth plate

KW - magnetic resonance imaging

KW - maturation process

KW - obesity

KW - puberty

U2 - 10.1111/apa.15617

DO - 10.1111/apa.15617

M3 - Article

C2 - 33047349

AN - SCOPUS:85094635288

VL - 110

SP - 1249

EP - 1256

JO - Acta Pædiatrica

JF - Acta Pædiatrica

SN - 1651-2227

IS - 4

ER -