A follow-up study of Nordic multiple sclerosis candidate gene regions

Research output: Contribution to journalArticle

Abstract

In this study, the results from three Nordic linkage disequilibrium screens in multiple sclerosis (MS) were investigated, in a new sample set of 314 Nordic MS trios from Denmark, Norway, Sweden and Iceland. Among 30 non-HLA and two HLA microsatellite markers individually genotyped, eight markers displayed distorted transmission with uncorrected P-value <0.05, ranked in this order: D6S2443 (6p21.32, HLA class II) (P corrected =0.01), D2S2201 (2p24), D19S552 (19q13), D3S3584 (3q21), D17S975 (17q11), DIS2627 (1p22), D6S273 (6p21.33, HLA class III) and D72S1051 (12q23). These non-HLA regions need further investigation as possible MS candidate gene regions in our population.

Details

Authors
  • P. Datta
  • H. F. Harbo
  • L. P. Ryder
  • E. Akesson
  • J. Benedikz
  • E. G. Celius
  • O. Andersen
  • K-M Myhe
  • Magnhild Sandberg Wollheim
  • J. Hillert
  • A. Svejgaard
  • P. S. Sorensen
  • A. Spurkland
  • A. Oturai
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • sclerosis, Nordic countries, multiple, LID screens, HLA, genetics, candidate regions, GAMES
Original languageEnglish
Pages (from-to)584-589
JournalMultiple Sclerosis
Volume13
Issue number5
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes