A galabiose-based two-dimensional scaffold for the synthesis of inhibitors targeting Pk- and P-antigen binding proteins.

Research output: Contribution to journalArticle


A disaccharide scaffold based on galabiose (Gal1–4Gal) was synthesized. Four different acceptors were evaluated in the -galactosylation and a relationship between the nucleophilicity, yield, and /-selectivity was found. The scaffold contains two orthogonal derivatisation sites, i.e. at O-2′ and the anomeric position, and as proof of concept, one derivatised galabioside was synthesized. Compounds based on this galabiose-scaffold are potential inhibitors of P- and Pk-antigen binding proteins.


Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry
Original languageEnglish
Pages (from-to)2785-2787
JournalTetrahedron Letters
Issue number14
Publication statusPublished - 2003
Publication categoryResearch

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)