A genetic linkage map of the laboratory rat, Rattus norvegicus

Research output: Contribution to journalArticle

Abstract

We report the construction of the first complete genetic linkage map of the laboratory rat. By testing 1171 simple sequence length polymorphisms (SSLPs), we have identified 432 markers that show polymorphisms between the SHR and BN rat strains and mapped them in a single (SHR × BN) F2 intercross. The loci define 21 large linkage groups corresponding to the 21 rat chromosomes, together with a pair of nearby markers on chromosome 9 that are not linked to the rest of the map. Because 99.5% of the markers fall into one of the 21 large linkage groups, the maps appear to cover the vast majority of the rat genome. The availability of the map should facilitate whole genome scans for genes underlying qualitative and quantitative traits relevant to mammalian physiology and pathobiology.

Details

Authors
  • Howard J. Jacob
  • Donna M. Brown
  • Ruth K. Bunker
  • Mark J. Daly
  • Victor J. Dzau
  • Alec Goodman
  • George Koike
  • Vladimir Kren
  • Theodore Kurtz
  • Åke Lernmark
  • Göran Levan
  • Yi pei Mao
  • Anna Pettersson
  • Michal Pravenec
  • Jason S. Simon
  • Claude Szpirer
  • Josiane Szpirer
  • Maria R. Trolliet
  • Eric S. Winer
  • Eric S. Lander
External organisations
  • Massachusetts General Hospital
  • Whitehead Institute for Biomedical Research
  • Stanford University
  • Charles University in Prague
  • University of Texas Health Science Centre
  • Karolinska Institutet
  • University of Gothenburg
  • Institute of Physiology of the Academy of Sciences of the Czech Republic
  • Free University of Brussels (ULB)
  • Massachusetts Institute of Technology
Original languageEnglish
Pages (from-to)63-69
JournalNature Genetics
Volume9
Issue number1
Publication statusPublished - 1995 Jan 1
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes