A genetic risk score for fasting plasma glucose is independently associatedwith arterial stiffness: A Mendelian randomization study

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@article{f777cf2199cd4689bfa3d7ef3f9e6b1a,
title = "A genetic risk score for fasting plasma glucose is independently associatedwith arterial stiffness: A Mendelian randomization study",
abstract = "Background: Arterial stiffness is known to be associated with a number of clinical conditions including hypertension, diabetes and dyslipidemia, and may predict cardiovascular events and mortality. However, causal links are hard to establish. Results from genome-wide association studies have identified only a few single nucleotide polymorphisms associated with arterial stiffness, the results have been inconsistent between studies and overlap with other clinical conditions is lacking. Our aim was to investigate a potential shared set of risk single nucleotide polymorphisms between relevant cardiometabolic traits and arterial stiffness. Method: The study population consisted of 2853 individuals (mean age 72 years, 40{\%} men) from the population-based Malm{\"o} Diet and Cancer study, Sweden. Carotid-femoral pulse wave velocity, a marker of arterial stiffness, was measured with Sphygmocor. Mendelian randomization analyses were performed using the twostage least square regression and multivariate inversevariance weighted methods. Results: There were positive associations between arterial stiffness and genetic risk scores for type 2 diabetes (β=0.03, P=0.04) and fasting plasma glucose (β=0.03, P=0.03), but not for systolic blood pressure, body mass index, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides. Multivariate inversevariance weighted methods confirmed the significant positive association for fasting plasma glucose β coefficients (P=0.006), but not for type 2 diabetes β coefficients (P=0.88). Conclusion: Genetically elevated fasting plasma glucose, but not genetically elevated risk of type 2 diabetes, was associated with arterial stiffness suggesting a causal stiffening effect of glycemia on the arterial wall, independently of type 2 diabetes.",
keywords = "Aging, Arterial stiffness, Diabetes mellitus, Epidemiology, Hyperglycemia, Mendelian randomization",
author = "Mikael Gotts{\"a}ter and George Hindy and Marju Orho-Melander and Nilsson, {Peter M.} and Olle Melander",
year = "2018",
doi = "10.1097/HJH.0000000000001646",
language = "English",
volume = "36",
pages = "809--814",
journal = "Journal of Hypertension",
issn = "1473-5598",
publisher = "Lippincott Williams & Wilkins",
number = "4",

}