A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.

Research output: Contribution to journalArticle

Abstract

Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10(-9)), 4q26 (rs6858698, P = 3.07 × 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10(-8)). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 × 10(-7)) and validated recently reported putative associations at 5p15.33 (TERT, rs10069690, P = 1.12 × 10(-10)) and 8q22.3 (rs2511714, P = 2.90 × 10(-9)). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL.

Details

Authors
  • Helen E Speedy
  • Maria Chiara Di Bernardo
  • Georgina P Sava
  • Martin J S Dyer
  • Amy Holroyd
  • Yufei Wang
  • Nicola J Sunter
  • Larry Mansouri
  • Karin E Smedby
  • Göran Roos
  • Sandrine Jayne
  • Aneela Majid
  • Claire Dearden
  • Andrew G Hall
  • Tryfonia Mainou-Fowler
  • Graham H Jackson
  • Geoffrey Summerfield
  • Robert J Harris
  • Andrew R Pettitt
  • David J Allsup
  • James R Bailey
  • Guy Pratt
  • Chris Pepper
  • Chris Fegan
  • Richard Rosenquist
  • Daniel Catovsky
  • James M Allan
  • Richard S Houlston
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology
Original languageEnglish
Pages (from-to)56
JournalNature Genetics
Volume46
Issue number1
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes