A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.

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Bibtex

@article{e1369ee9f63b414e93f2d300a26a87ea,
title = "A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.",
abstract = "Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10(-9)), 4q26 (rs6858698, P = 3.07 × 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10(-8)). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 × 10(-7)) and validated recently reported putative associations at 5p15.33 (TERT, rs10069690, P = 1.12 × 10(-10)) and 8q22.3 (rs2511714, P = 2.90 × 10(-9)). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL.",
author = "Speedy, {Helen E} and {Di Bernardo}, {Maria Chiara} and Sava, {Georgina P} and Dyer, {Martin J S} and Amy Holroyd and Yufei Wang and Sunter, {Nicola J} and Larry Mansouri and Gunnar Juliusson and Smedby, {Karin E} and G{\"o}ran Roos and Sandrine Jayne and Aneela Majid and Claire Dearden and Hall, {Andrew G} and Tryfonia Mainou-Fowler and Jackson, {Graham H} and Geoffrey Summerfield and Harris, {Robert J} and Pettitt, {Andrew R} and Allsup, {David J} and Bailey, {James R} and Guy Pratt and Chris Pepper and Chris Fegan and Richard Rosenquist and Daniel Catovsky and Allan, {James M} and Houlston, {Richard S}",
year = "2014",
doi = "10.1038/ng.2843",
language = "English",
volume = "46",
pages = "56",
journal = "Nature Genetics",
issn = "1546-1718",
publisher = "Nature Publishing Group",
number = "1",

}