A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity.

Research output: Contribution to journalArticle

Abstract

Maturity-onset diabetes of the young (MODY) is a heterogeneous single gene disorder characterized by non–insulin-dependent diabetes, an early onset and autosomal dominant inheritance. Mutations in six genes have been shown to cause MODY. Approximately 15–20% of families fitting MODY criteria do not have mutations in any of the known genes. These families provide a rich resource for the identification of new MODY genes. This will potentially enable further dissection of clinical heterogeneity and bring new insights into mechanisms of β-cell dysfunction. To facilitate the identification of novel MODY loci, we combined the results from three genome-wide scans on a total of 23 families fitting MODY criteria. We used both a strict parametric model of inheritance with heterogeneity and a model-free analysis. We did not identify any single novel locus but provided putative evidence for linkage to chromosomes 6 (nonparametric linkage [NPL]score 2.12 at 71 cM) and 10 (NPL score 1.88 at 169–175 cM), and to chromosomes 3 (heterogeneity LOD [HLOD] score 1.27 at 124 cM) and 5 (HLOD score 1.22 at 175 cM) in 14 more strictly defined families. Our results provide evidence for further heterogeneity in MODY.

Details

Authors
  • Timothy M. Frayling
  • Cecilia Lindgren
  • Jean Claude Chevre
  • Stephan Menzel
  • Marie Wishart
  • Yamina Benmezroua
  • Alison Brown
  • Julie C. Evans
  • Pamidghantam Subba Rao
  • Christian Dina
  • Cécile Lecoeur
  • Timo Kanninen
  • Peter Almgren
  • Michael P. Bulman
  • Youxiang Wang
  • James Mills
  • Rosemarie Wright-Pascoe
  • Melanie M. Mahtani
  • Francesco Prisco
  • Angels Costa
  • Ignacio Cognet
  • Torben Hansen
  • Oluf Pedersen
  • Sian Ellard
  • Tiinamaija Tuomi
  • Philippe Froguel
  • Andrew T. Hattersley
  • Martine Vaxillaire
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes
Original languageEnglish
Pages (from-to)872-881
JournalDiabetes
Volume52
Issue number3
Publication statusPublished - 2003
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Endocrinology (013241500), Pediatrics/Urology/Gynecology/Endocrinology (013240400), Diabetes and Endocrinology (013241530)