A high-stringency blueprint of the human proteome

Research output: Contribution to journalReview article

Abstract

The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.

Details

Authors
  • Subash Adhikari
  • Edouard C. Nice
  • Eric W. Deutsch
  • Lydie Lane
  • Gilbert S. Omenn
  • Stephen R. Pennington
  • Young Ki Paik
  • Christopher M. Overall
  • Fernando J. Corrales
  • Ileana M. Cristea
  • Jennifer E. Van Eyk
  • Mathias Uhlén
  • Cecilia Lindskog
  • Daniel W. Chan
  • Amos Bairoch
  • James C. Waddington
  • Joshua L. Justice
  • Joshua LaBaer
  • Henry Rodriguez
  • Fuchu He
  • Markus Kostrzewa
  • Peipei Ping
  • Rebekah L. Gundry
  • Peter Stewart
  • Sanjeeva Srivastava
  • Sudhir Srivastava
  • Fabio C.S. Nogueira
  • Gilberto B. Domont
  • Yves Vandenbrouck
  • Maggie P.Y. Lam
  • Sara Wennersten
  • Juan Antonio Vizcaino
  • Marc Wilkins
  • Jochen M. Schwenk
  • Emma Lundberg
  • Nuno Bandeira
  • Susan T. Weintraub
  • Charles Pineau
  • Ulrike Kusebauch
  • Robert L. Moritz
  • Seong Beom Ahn
  • Magnus Palmblad
  • Michael P. Snyder
  • Ruedi Aebersold
  • Mark S. Baker
Organisations
External organisations
  • Macquarie University, Sydney
  • Monash University
  • Institute for Systems Biology, Seattle
  • University of Michigan
  • University College Dublin
  • Yonsei Proteome Research Center
  • University of British Columbia
  • Carlos III Health Institute
  • Princeton University
  • Cedars-Sinai Medical Center
  • KTH Royal Institute of Technology
  • Uppsala University
  • Arizona State University
  • National Cancer Institute, USA
  • Royal Prince Alfred Hospital
  • University Grenoble Alpes
  • University of Colorado
  • European Bioinformatics Institute
  • University of New South Wales
  • Leiden University Medical Centre
  • Stanford University
  • University of Zurich
  • University of Geneva
  • Johns Hopkins University
  • National Center for Protein Sciences
  • Bruker Daltonik GmbH
  • University of California, Los Angeles
  • University of Nebraska
  • Indian Institute of Technology, Bombay
  • Federal University of Rio de Janeiro
  • University of California, San Diego
  • University of Texas
  • University of Texas Health Science Centre
  • University of Rennes I
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Genetics
Original languageEnglish
Article number5301
JournalNature Communications
Volume11
Issue number1
Publication statusPublished - 2020
Publication categoryResearch
Peer-reviewedYes