A high-stringency blueprint of the human proteome

Research output: Contribution to journalReview article


title = "A high-stringency blueprint of the human proteome",
abstract = "The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP{\textquoteright}s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.",
author = "Subash Adhikari and Nice, {Edouard C.} and Deutsch, {Eric W.} and Lydie Lane and Omenn, {Gilbert S.} and Pennington, {Stephen R.} and Paik, {Young Ki} and Overall, {Christopher M.} and Corrales, {Fernando J.} and Cristea, {Ileana M.} and {Van Eyk}, {Jennifer E.} and Mathias Uhl{\'e}n and Cecilia Lindskog and Chan, {Daniel W.} and Amos Bairoch and Waddington, {James C.} and Justice, {Joshua L.} and Joshua LaBaer and Henry Rodriguez and Fuchu He and Markus Kostrzewa and Peipei Ping and Gundry, {Rebekah L.} and Peter Stewart and Sanjeeva Srivastava and Sudhir Srivastava and Nogueira, {Fabio C.S.} and Domont, {Gilberto B.} and Yves Vandenbrouck and Lam, {Maggie P.Y.} and Sara Wennersten and Vizcaino, {Juan Antonio} and Marc Wilkins and Schwenk, {Jochen M.} and Emma Lundberg and Nuno Bandeira and Gyorgy Marko-Varga and Weintraub, {Susan T.} and Charles Pineau and Ulrike Kusebauch and Moritz, {Robert L.} and Ahn, {Seong Beom} and Magnus Palmblad and Snyder, {Michael P.} and Ruedi Aebersold and Baker, {Mark S.}",
year = "2020",
doi = "10.1038/s41467-020-19045-9",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",