A high-stringency blueprint of the human proteome

Research output: Contribution to journalReview article

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A high-stringency blueprint of the human proteome. / Adhikari, Subash; Nice, Edouard C.; Deutsch, Eric W.; Lane, Lydie; Omenn, Gilbert S.; Pennington, Stephen R.; Paik, Young Ki; Overall, Christopher M.; Corrales, Fernando J.; Cristea, Ileana M.; Van Eyk, Jennifer E.; Uhlén, Mathias; Lindskog, Cecilia; Chan, Daniel W.; Bairoch, Amos; Waddington, James C.; Justice, Joshua L.; LaBaer, Joshua; Rodriguez, Henry; He, Fuchu; Kostrzewa, Markus; Ping, Peipei; Gundry, Rebekah L.; Stewart, Peter; Srivastava, Sanjeeva; Srivastava, Sudhir; Nogueira, Fabio C.S.; Domont, Gilberto B.; Vandenbrouck, Yves; Lam, Maggie P.Y.; Wennersten, Sara; Vizcaino, Juan Antonio; Wilkins, Marc; Schwenk, Jochen M.; Lundberg, Emma; Bandeira, Nuno; Marko-Varga, Gyorgy; Weintraub, Susan T.; Pineau, Charles; Kusebauch, Ulrike; Moritz, Robert L.; Ahn, Seong Beom; Palmblad, Magnus; Snyder, Michael P.; Aebersold, Ruedi; Baker, Mark S.

In: Nature Communications, Vol. 11, No. 1, 5301, 2020.

Research output: Contribution to journalReview article

Harvard

Adhikari, S, Nice, EC, Deutsch, EW, Lane, L, Omenn, GS, Pennington, SR, Paik, YK, Overall, CM, Corrales, FJ, Cristea, IM, Van Eyk, JE, Uhlén, M, Lindskog, C, Chan, DW, Bairoch, A, Waddington, JC, Justice, JL, LaBaer, J, Rodriguez, H, He, F, Kostrzewa, M, Ping, P, Gundry, RL, Stewart, P, Srivastava, S, Srivastava, S, Nogueira, FCS, Domont, GB, Vandenbrouck, Y, Lam, MPY, Wennersten, S, Vizcaino, JA, Wilkins, M, Schwenk, JM, Lundberg, E, Bandeira, N, Marko-Varga, G, Weintraub, ST, Pineau, C, Kusebauch, U, Moritz, RL, Ahn, SB, Palmblad, M, Snyder, MP, Aebersold, R & Baker, MS 2020, 'A high-stringency blueprint of the human proteome', Nature Communications, vol. 11, no. 1, 5301. https://doi.org/10.1038/s41467-020-19045-9

APA

Adhikari, S., Nice, E. C., Deutsch, E. W., Lane, L., Omenn, G. S., Pennington, S. R., Paik, Y. K., Overall, C. M., Corrales, F. J., Cristea, I. M., Van Eyk, J. E., Uhlén, M., Lindskog, C., Chan, D. W., Bairoch, A., Waddington, J. C., Justice, J. L., LaBaer, J., Rodriguez, H., ... Baker, M. S. (2020). A high-stringency blueprint of the human proteome. Nature Communications, 11(1), [5301]. https://doi.org/10.1038/s41467-020-19045-9

CBE

Adhikari S, Nice EC, Deutsch EW, Lane L, Omenn GS, Pennington SR, Paik YK, Overall CM, Corrales FJ, Cristea IM, Van Eyk JE, Uhlén M, Lindskog C, Chan DW, Bairoch A, Waddington JC, Justice JL, LaBaer J, Rodriguez H, He F, Kostrzewa M, Ping P, Gundry RL, Stewart P, Srivastava S, Srivastava S, Nogueira FCS, Domont GB, Vandenbrouck Y, Lam MPY, Wennersten S, Vizcaino JA, Wilkins M, Schwenk JM, Lundberg E, Bandeira N, Marko-Varga G, Weintraub ST, Pineau C, Kusebauch U, Moritz RL, Ahn SB, Palmblad M, Snyder MP, Aebersold R, Baker MS. 2020. A high-stringency blueprint of the human proteome. Nature Communications. 11(1):Article 5301. https://doi.org/10.1038/s41467-020-19045-9

MLA

Vancouver

Adhikari S, Nice EC, Deutsch EW, Lane L, Omenn GS, Pennington SR et al. A high-stringency blueprint of the human proteome. Nature Communications. 2020;11(1). 5301. https://doi.org/10.1038/s41467-020-19045-9

Author

Adhikari, Subash ; Nice, Edouard C. ; Deutsch, Eric W. ; Lane, Lydie ; Omenn, Gilbert S. ; Pennington, Stephen R. ; Paik, Young Ki ; Overall, Christopher M. ; Corrales, Fernando J. ; Cristea, Ileana M. ; Van Eyk, Jennifer E. ; Uhlén, Mathias ; Lindskog, Cecilia ; Chan, Daniel W. ; Bairoch, Amos ; Waddington, James C. ; Justice, Joshua L. ; LaBaer, Joshua ; Rodriguez, Henry ; He, Fuchu ; Kostrzewa, Markus ; Ping, Peipei ; Gundry, Rebekah L. ; Stewart, Peter ; Srivastava, Sanjeeva ; Srivastava, Sudhir ; Nogueira, Fabio C.S. ; Domont, Gilberto B. ; Vandenbrouck, Yves ; Lam, Maggie P.Y. ; Wennersten, Sara ; Vizcaino, Juan Antonio ; Wilkins, Marc ; Schwenk, Jochen M. ; Lundberg, Emma ; Bandeira, Nuno ; Marko-Varga, Gyorgy ; Weintraub, Susan T. ; Pineau, Charles ; Kusebauch, Ulrike ; Moritz, Robert L. ; Ahn, Seong Beom ; Palmblad, Magnus ; Snyder, Michael P. ; Aebersold, Ruedi ; Baker, Mark S. / A high-stringency blueprint of the human proteome. In: Nature Communications. 2020 ; Vol. 11, No. 1.

RIS

TY - JOUR

T1 - A high-stringency blueprint of the human proteome

AU - Adhikari, Subash

AU - Nice, Edouard C.

AU - Deutsch, Eric W.

AU - Lane, Lydie

AU - Omenn, Gilbert S.

AU - Pennington, Stephen R.

AU - Paik, Young Ki

AU - Overall, Christopher M.

AU - Corrales, Fernando J.

AU - Cristea, Ileana M.

AU - Van Eyk, Jennifer E.

AU - Uhlén, Mathias

AU - Lindskog, Cecilia

AU - Chan, Daniel W.

AU - Bairoch, Amos

AU - Waddington, James C.

AU - Justice, Joshua L.

AU - LaBaer, Joshua

AU - Rodriguez, Henry

AU - He, Fuchu

AU - Kostrzewa, Markus

AU - Ping, Peipei

AU - Gundry, Rebekah L.

AU - Stewart, Peter

AU - Srivastava, Sanjeeva

AU - Srivastava, Sudhir

AU - Nogueira, Fabio C.S.

AU - Domont, Gilberto B.

AU - Vandenbrouck, Yves

AU - Lam, Maggie P.Y.

AU - Wennersten, Sara

AU - Vizcaino, Juan Antonio

AU - Wilkins, Marc

AU - Schwenk, Jochen M.

AU - Lundberg, Emma

AU - Bandeira, Nuno

AU - Marko-Varga, Gyorgy

AU - Weintraub, Susan T.

AU - Pineau, Charles

AU - Kusebauch, Ulrike

AU - Moritz, Robert L.

AU - Ahn, Seong Beom

AU - Palmblad, Magnus

AU - Snyder, Michael P.

AU - Aebersold, Ruedi

AU - Baker, Mark S.

PY - 2020

Y1 - 2020

N2 - The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.

AB - The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.

U2 - 10.1038/s41467-020-19045-9

DO - 10.1038/s41467-020-19045-9

M3 - Review article

C2 - 33067450

AN - SCOPUS:85092744472

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 5301

ER -