A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse.

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Abstract

Neurogenesis is restricted in the adult mammalian brain; most neurons are neither exchanged during normal life nor replaced in pathological situations. We report that stroke elicits a latent neurogenic program in striatal astrocytes in mice. Notch1 signaling is reduced in astrocytes after stroke, and attenuated Notch1 signaling is necessary for neurogenesis by striatal astrocytes. Blocking Notch signaling triggers astrocytes in the striatum and the medial cortex to enter a neurogenic program, even in the absence of stroke, resulting in 850 ± 210 (mean ± SEM) new neurons in a mouse striatum. Thus, under Notch signaling regulation, astrocytes in the adult mouse brain parenchyma carry a latent neurogenic program that may potentially be useful for neuronal replacement strategies.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences
  • Cancer and Oncology
  • Neurology
Original languageEnglish
Pages (from-to)237-241
JournalScience
Volume346
Issue number6206
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurology, Lund (013027000), Neuronal Survival (013212041), Division of Translational Cancer Research (013250500)