A longitudinal analysis of the relationships of physical activity and body fat with nerve growth factor and brain-derived neural factor in children

Research output: Contribution to journalArticle

Abstract

Background: Nerve growth factor (NGF) and brain-derived neural factor (BDNF) are important for brain function and detectable in the blood. This study explored the longitudinal associations of physical activity and body fat with serum NGF and BDNF in children. Methods: Two waves of measurements were performed 2 years apart in 8- to 11-year-old children, including physical activity using the ActiGraph model 7164, body composition by dual-energy X-ray absorptiometry, and serum NGF and BDNF determined by multiplex immunoassay. The first wave included 248 children. Full information maximum likelihood estimation with robust standard errors was applied in structural equation modeling. Results: Vigorous physical activity showed a direct positive longitudinal relationship with NGF (standardized coefficient β = 0.30, P = .01) but not with BDNF (β = 0.04, P = .84). At the same time, body fat percentage was positively related to both NGF (β = 0.59, P < .001) and BDNF (β = 0.17, P = .04). There was an indication of an indirect relationship of vigorous physical activity with NGF (product of unstandardized coefficient β = −0.18, P = .02) and BDNF (β = −0.07, P = .05) through the negative relationship with body fat percentage (β = −0.36, P < .001). Conclusions: Vigorous physical activity is directly related to serum NGF and indirectly through the level of body fat. The relationships with serum BDNF are more complex.

Details

Authors
Organisations
External organisations
  • University of Gothenburg
  • Western Norway University of Applied Sciences
  • Norwegian School of Sport Sciences
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Nutrition and Dietetics
  • Sport and Fitness Sciences

Keywords

  • Accelerometer, Dual-energy X-ray absorptiometry, Neurotrophins, Serum, Structural equation modeling
Original languageEnglish
Pages (from-to)620-625
Number of pages6
JournalJournal of Physical Activity and Health
Volume15
Issue number8
Publication statusPublished - 2018 Aug 1
Publication categoryResearch
Peer-reviewedYes