A longitudinal analysis of the relationships of physical activity and body fat with nerve growth factor and brain-derived neural factor in children

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T1 - A longitudinal analysis of the relationships of physical activity and body fat with nerve growth factor and brain-derived neural factor in children

AU - Arvidsson, Daniel

AU - Johannesson, Elias

AU - Andersen, Lars Bo

AU - Karlsson, Magnus

AU - Wollmer, Per

AU - Thorsson, Ola

AU - Dencker, Magnus

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Background: Nerve growth factor (NGF) and brain-derived neural factor (BDNF) are important for brain function and detectable in the blood. This study explored the longitudinal associations of physical activity and body fat with serum NGF and BDNF in children. Methods: Two waves of measurements were performed 2 years apart in 8- to 11-year-old children, including physical activity using the ActiGraph model 7164, body composition by dual-energy X-ray absorptiometry, and serum NGF and BDNF determined by multiplex immunoassay. The first wave included 248 children. Full information maximum likelihood estimation with robust standard errors was applied in structural equation modeling. Results: Vigorous physical activity showed a direct positive longitudinal relationship with NGF (standardized coefficient β = 0.30, P = .01) but not with BDNF (β = 0.04, P = .84). At the same time, body fat percentage was positively related to both NGF (β = 0.59, P < .001) and BDNF (β = 0.17, P = .04). There was an indication of an indirect relationship of vigorous physical activity with NGF (product of unstandardized coefficient β = −0.18, P = .02) and BDNF (β = −0.07, P = .05) through the negative relationship with body fat percentage (β = −0.36, P < .001). Conclusions: Vigorous physical activity is directly related to serum NGF and indirectly through the level of body fat. The relationships with serum BDNF are more complex.

AB - Background: Nerve growth factor (NGF) and brain-derived neural factor (BDNF) are important for brain function and detectable in the blood. This study explored the longitudinal associations of physical activity and body fat with serum NGF and BDNF in children. Methods: Two waves of measurements were performed 2 years apart in 8- to 11-year-old children, including physical activity using the ActiGraph model 7164, body composition by dual-energy X-ray absorptiometry, and serum NGF and BDNF determined by multiplex immunoassay. The first wave included 248 children. Full information maximum likelihood estimation with robust standard errors was applied in structural equation modeling. Results: Vigorous physical activity showed a direct positive longitudinal relationship with NGF (standardized coefficient β = 0.30, P = .01) but not with BDNF (β = 0.04, P = .84). At the same time, body fat percentage was positively related to both NGF (β = 0.59, P < .001) and BDNF (β = 0.17, P = .04). There was an indication of an indirect relationship of vigorous physical activity with NGF (product of unstandardized coefficient β = −0.18, P = .02) and BDNF (β = −0.07, P = .05) through the negative relationship with body fat percentage (β = −0.36, P < .001). Conclusions: Vigorous physical activity is directly related to serum NGF and indirectly through the level of body fat. The relationships with serum BDNF are more complex.

KW - Accelerometer

KW - Dual-energy X-ray absorptiometry

KW - Neurotrophins

KW - Serum

KW - Structural equation modeling

U2 - 10.1123/jpah.2017-0483

DO - 10.1123/jpah.2017-0483

M3 - Article

VL - 15

SP - 620

EP - 625

JO - Journal of Physical Activity and Health

T2 - Journal of Physical Activity and Health

JF - Journal of Physical Activity and Health

SN - 1543-5474

IS - 8

ER -