A low body temperature on arrival at hospital following out-of-hospital-cardiac-arrest is associated with increased mortality in the TTM-study

Research output: Contribution to journalArticle


Aim To investigate the association of temperature on arrival to hospital after out-of-hospital-cardiac arrest (OHCA) with the primary outcome of mortality, in the targeted temperature management (TTM) trial. Methods The TTM trial randomized 939 patients to TTM at 33 or 36 °C for 24 h. Patients were categorized according to their recorded body temperature on arrival and also categorized to groups of patients being actively cooled or passively rewarmed. Results OHCA patients having a temperature ≤34.0 °C on arrival at hospital had a significantly higher mortality compared to the OHCA patients with a higher temperature on arrival. A low body temperature on arrival was associated with a longer time to return of spontaneous circulation (ROSC) and duration of transport time to hospital. Patients who were actively cooled or passively rewarmed during the first 4 h had similar mortality. In a multivariate logistic regression model mortality was significantly related to time from OHCA to ROSC, time from OHCA to advanced life support (ALS), age, sex and first registered rhythm. None of the temperature related variables (included the TTM-groups) were significantly related to mortality. Conclusion OHCA patients with a temperature ≤34.0 °C on arrival have a higher mortality than patients with a temperature ≥34.1 °C on arrival. A low temperature on arrival is associated with a long time to ROSC. Temperature changes and TTM-groups were not associated with mortality in a regression model.


External organisations
  • University of Oslo
  • Helsingborg Hospital
  • Copenhagen University Hospital
  • Geneva University Hospital
  • Medical Center Leeuwarden
  • Centre Hospitalier de Luxembourg
  • University Hospital of Wales
  • Liverpool Hospital
  • Oslo university hospital
  • Skåne University Hospital
  • Academic Medical Center of University of Amsterdam (AMC)
  • Santa Maria degli Angeli Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems


  • Body temperature on arrival at hospital, Cardiac arrest, Temperature management
Original languageEnglish
Pages (from-to)102-106
Number of pages5
Publication statusPublished - 2016 Oct 1
Publication categoryResearch