A mathematical model for measuring blood flow in skeletal muscle with the microdialysis ethanol technique

Research output: Contribution to journalArticle

Abstract

A theoretical analysis of the microdialysis ethanol technique in skeletal muscle is presented, and a model governing the transport of ethanol from the microdialysis probe to the capillaries in the muscle tissue is proposed. The model is derived under the assumption of a steady-state situation, and an analytical solution is found for the outflow-to-inflow ratio of ethanol in the perfusate. Theoretically calculated results are compared with experiments, and for at least one of the two probe types used good agreement is achieved in a wide range of blood flow and perfusate flow rates. The main uncertainty factor in the theoretical calculations is the diffusivity of ethanol in muscle tissue, and the value for best agreement between theory and experiments has been used. Error estimates show that for a constant relative error in the outflow-to-inflow ratio of ethanol in the perfusate, low perfusate flow rates give better predictions of the blood flow.

Details

Authors
  • F Wallgren
  • G Amberg
  • R C Hickner
  • Ulf Ekelund
  • L Jorfeldt
  • J Henriksson
External organisations
  • External Organization - Unknown
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Physiology
Original languageEnglish
Pages (from-to)648-659
JournalJournal of Applied Physiology
Volume79
Issue number2
Publication statusPublished - 1995
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes