A melanoma és az agyi áttétképzödés molekuláris háttere

Research output: Contribution to journalReview article

Abstract

Malignant melanoma is one of the most aggressive tumors which often gives metastasis to distant organs thereby limiting the chances of survival. Brain metastasis occurs in nearly half of the advanced tumors. In order to improve outcome early diagnosis is important. The discovery and better understanding of genetic and epigenetic changes is essential for developing new effective therapies, which can designate promising therapeutic targets. Melanoma most often is caused by gene mutations of the mitogen-activated protein kinase pathway, the phosphatidylinositol 3-kinase signaling pathway, and the cell cycle regulatory molecules, respectively. The molecular process of brain metastasis has not been fully elucidated. In our review we summarize the genetic alterations and molecular mechanisms playing a role in the development of melanoma and its brain metastasis.

Details

Authors
Organisations
External organisations
  • University of Debrecen
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • Brain metastasis, Melanoma, Metastasis
Translated title of the contributionMolecular background of the melanoma and the brain metastasis
Original languageOther
Pages (from-to)1083-1091
Number of pages9
JournalOrvosi Hetilap
Volume158
Issue number28
Publication statusPublished - 2017 Jul 1
Publication categoryResearch
Peer-reviewedYes