A meroterpenoid NF-kappa B inhibitor and drimane sesquiterpenoids from asafetida

Research output: Contribution to journalArticle

Abstract

Investigation of an acetone extract from asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappa B-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.

Details

Authors
  • Giovanni Appendino
  • Lucia Maxia
  • Marcelo Bascope
  • Peter J. Houghton
  • Gonzalo Sanchez-Duffhues
  • Eduardo Munoz
  • Olov Sterner
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry
Original languageEnglish
Pages (from-to)1101-1104
JournalJournal of Natural Products
Volume69
Issue number7
Publication statusPublished - 2006
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)