A new approach to detection of antigen-antibody complexes by microcalorimetric measurements of heat production in blood cells

Research output: Contribution to journalArticle

Abstract

Using batch microcalorimeters of the thermopile conduction type, heat production was measured in human blood in the presence of defined antigens and their specific antibodies. A large increase in heat production, reflecting increased metabolic activity in the blood cells, was found when antigens and specific antisera at certain antigen-antibody proportions were mixed with the blood. The reproducibility and specificity of the method were found to be very good. The present results indicate that calorimetry may be a useful technique for detection of antigen-antibody complexes.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology
Original languageEnglish
Pages (from-to)29-37
JournalJournal of Immunological Methods
Volume37
Issue number1
Publication statusPublished - 1980
Publication categoryResearch
Peer-reviewedYes